41.176 HzPaul Samuel Guarino
Benchmarked · patent pending

Klein Biodefense

Biological threat detection and early warning
Biosurveillance · public health

A deterministic outbreak and contamination detection engine. It reads public-health and environmental time series and flags the onset, escalation and severe phases of an event.

What it is

An early-warning system’s job is not to declare an emergency. It is to say something changed, investigate now, early enough that people have time to verify before a decision becomes irreversible.

Klein Biodefense is built for early warning, not for clinical diagnosis. Given the same data and the same configuration it produces the same result every time, so an independent lab, a university or a critic can reproduce it.

What it does

Yap Island dengue, 2011–2012

Real recorded data

A retrospective test on 185 daily surveillance observations: real reported case data, not a simulated curve, and not data the system was trained on.

85 days
Before the outbreak’s peak, on the day of the first reported case
0.9966
F1 (precision 0.9933, recall 1.0000) against 978 total cases
70 days
Before peak with the absolute-threshold tier deliberately removed

This is same-day detection of the first visible case in a historical dataset. Operational use calls for independent validation under frozen, blinded protocols, and that validation is invited.

Benchmarked real-world events

Real recorded data

Every row is a real event, scored on its real recorded data.

EventRecordsDetectedMissedFalse alarmsRecall
Flint lead crisis3110001.0000
Bethpage TCE plume61001.0000
East Palestine derailment3311001.0000
Daily asbestos events3,4993,499001.0000
COVID-19, New York daily cases1,065799001.0000
Ebola, West Africa (WHO 2014–2016)12298001.0000

Where it fits

Patent pending (U.S. non-provisional application; priority June 2025).

Read more

Licensing & collaboration

Offered for licensing, not for sale. Independent validation, engineering collaboration and research partnerships are welcome.

[email protected]

Inventor: Paul Samuel Guarino, Independent Researcher & Inventor